MCQs: Gastroretentive Drug Delivery Systems (GRDDS).

MCQs: Gastroretentive Drug Delivery Systems (GRDDS).

Quiz

  

Atttempt as many times u like within 45 minutes.

 

1. Which of the following is not a part of Stomach?
   1.   Cardia
   2.   Fundus
   3.   Pylorus
   4.   Ramus
2. Which glands in the stomach produces gastric acid?
   1.   Parietal Cells.
   2.   Chief Cells.
   3.   Surface Cells
   4.   Mucous Neck Cells
3. Which of the following is an criteria for selection of the drug candidate for GRDDS,
   1.   Low absorption window,
   2.   Highly potent drug.
   3.   Smaller therapeutic window.
   4.   Faster onset of action.
4. Which of the following is a prominent disadvantage of Floating Drug Delivery Systems.
   1.   Gas production.
   2.   Requirement of high levels of stomach fluids to float.
   3.   Suprainfection.
   4.   Contact dermatitis.
5. Identify the approach not useful to increase gastric retention time for GRDDS.
   1.   High density Systems.
   2.   Floating Systems.
   3.   Swelling Systems.
   4.   Compressing Systems.
6. Conventional hydrogels usually have porous size of 10μm hence require much time to reach equilibrium while their modified version “Superporous Hydrogels' ' reach equilibrium faster has an average pore size of …..
   1.   >100μm
   2.   > 100nm
   3.   10μm
   4.   10nm
7. Floating Drug Delivery Systems are hydrodynamically balanced systems that have a bulk density -------.
   1.   Same that of Gastric fluids.
   2.   Lesser than that of Gastric Fluid.
   3.   More than that of Gastric Fluid.
   4.   Same that of Gastric Acid.
8. Which ofthe following is not a type of Floating Drug Delivery System.
   1.   Effervescent Systems.
   2.   Non Effervescent Systems.
   3.   Raft Forming Systems.
   4.   Metered Dosing Systems.
9. Which of the following is not a matrix forming polymer?
   1.   Chitosan
   2.   Polystyrene
   3.   Polyacrylate
   4.   Polycarbonate
10. Which of the following is not a “Hydrocolloid”?
    1.   Chitosan
    2.   HPMC
    3.   HEC
    4.   Polycarbonate
11. Which one of the following is a wrong statement for GRDDS.
    1.   Useful to provide both local and systemic effects of the drug
    2.   Useful to increase gastric retention of the drug
    3.   Useful to reduce the first pass effect of the drug.
    4.   Useful to target site specific release of the drugs
12. Hollow microspheres are a non effervescent approach for GRDDS are also known as,
    1.   Microballs
    2.   Microballoons
    3.   Floating Beads
    4.   Alginate beads
13. Which of the following is used to increase the density,
    1.   Potassium permanganate.
    2.   Boric Acid.
    3.   Iron Powder.
    4.   Glucose Powder.
14. Which of the following GRDDS is also known as “Plug Type System”.
    1.   Floating Systems.
    2.   Swelling Systems.
    3.   Bioadhesive Systems.
    4.   Pulsatile System.
15. Which of the following is used to produce effervescence in Floating drug delivery systems.
    1.   Sodium Bi Carbonate.
    2.   Magnesium Stearate.
    3.   Sorbitol.
    4.   Talc.
16. The time for which the floating dosage form floats on dissolution medium is called,
    1.   Floating Time.
    2.   Buoyancy Lag Time.
    3.   Lead Time.
    4.   Transit Time.
17. The time taken by dosage form to reach the top of dissolution medium after placing in the medium is termed as,
    1.   Floating Time.
    2.   Buoyancy Lag Time.
    3.   Lead Time.
    4.   Transit Time.
18. Which of the following classes of the drug is not a candidate for GRDDS.
    1.   Drugs with good acid solubility.
    2.   Drugs with high plasma protein binding.
    3.   Drugs with less first pass metabolism
    4.   Drugs which are sensitive to acid.
19. Polybrene, Polylysine and dextran Sodium are used as ---------- .
    1.   Drug release accelerants.
    2.   Penetration enhancers.
    3.   Bioadhesive polymers.
    4.   Effervescence producers.
20. Which of the following is not an evaluation parameter of GRDDS.
    1.   Floating Time.
    2.   Specific gravity.
    3.   Bioadhesive strength.
    4.   Conductivity Test.